Analysis were done using Fisher Exact t test and Chi square test.\n\nMean gestational age was 34.87(3.86) wk and 33.7(3.29) wk in the test and control groups respectively, while mean BW was 2186.02(814.57) g and 1851.2(592.93) g in each respective group. In the test group 10 were symptomatic, 5 were on mechanical ventilation, 8 were on CPAP and one was
post-operation case. Difference in the incidence of significant RI in test and control group was not statistically significant. Incidence between various group of neonates in test group showed no statistical significance either. However, the incidence of grade IV reflux in test group was 8/24 and control 0/10 and this difference was statistically significant. Reflux did increase when period of gestation decreased and the difference was statistically significant.\n\nClinically significant grade IV GER was more in high risk (test) neonates than control.”
“Well-defined temperature-responsive 3-Methyladenine S3I-201 polymers were covalently conjugated to model proteins by two consecutive Michael addition thiol-ene reactions. Poly(N-isopropylacrylamide) (PNIPAM) prepared by
reversible addition fragmentation chain transfer (RAFT) polymerization was aminolyzed to yield thiol-terminated chains that were subsequently reacted with excess 1,8-bis-maleimidodiethyleneglycol. The resulting maleimide-terminated polymer was reacted with bovine serum albumin and ovalbumin to yield polymer protein conjugates by a “grafting-to” approach. The thermoresponsive nature of PNIPAM was conferred to the conjugate, as demonstrated by dynamic light scattering analysis that indicated the formation of intermolecular aggregates at elevated temperatures.”
“Acute and chronic Entinostat toxicities of the water extract from calyces of Hibiscus sabdariffa were studied
in male and female rats. After 14 days of a single oral administration of test substance 5,000 mg/kg body weight, measurement of the body and organ weights, necropsy and health monitoring were performed. No signs and differences of the weights or behaviour compared to the control rats were observed. The results indicated that the single oral administration of H. sabdariffa extract in the amount of 5,000 mg/kg body weight does not produce acute toxicity. The chronic toxicity was determined by oral feeding both male and female rats daily with the extract at the doses of 50, 100, and 200 mg/kg body weight for 270 days. The examinations of signs, animal behaviour and health monitoring showed no defects in the test groups compared to the control groups. Both test and control groups (day 270th) and satellite group (day 298th) were analysed by measuring their final body and organ weights, taking necropsy, and examining haematology, blood clinical chemistry, and microanatomy. Results showed no differences from the control groups. Overall, our study demonstrated that an oral administration of H.